This region brings together 100 municipalities and is Portugal's largest and most diverse tourist region. It is home to cities such as Aveiro, Castelo Branco, Coimbra, Covilhã, Figueira da Foz, Guarda, Leiria, Óbidos, Ourém, Ovar, Torres Novas, Nazaré, Viseu and Vouzela. From schist and mountain villages to medieval towns, from convents and monasteries to castles and defensive walls, this is the region with the biggest waves in the world (Nazaré), home to the largest mountain range in Portugal (Serra da Estrela), the largest tourist caves (Mira de Aire), the most Portuguese village (Monsanto) and the largest pine forest in Portugal (Leiria), once planted on the initiative of a King who took the name of Lavrador (Farmer). Here took place of one of the most dramatic chapters in the love story of King Pedro and his love, Inês. This is where the first Portuguese university is located.

The cultivation of vines goes back to Roman times, and thus the four demarcated regions brought together in this tourist region are an attribute of valorisation of the territory, with wine being a strong element in the preservation and construction of the landscape and intangible heritage. The wine offer is vast, ranging from the sparkling wines of Bairrada, on the Atlantic coast, to the red wines of Dão, inland and the birthplace of Touriga Nacional and Encruzado, from the rosé wines of Beira Interior, with its high-altitude vineyards close to the Spanish border, to the wines that are born in the only wine-growing community located next to the River Tejo, right in the centre of Portugal, and whose soils define its three very distinct terroirs - Bairro, Campo and Charneca.